/*--------------investigator-initiated-studies---------------*/
/******************diversity-inclusion-page*****************/
.paragraph-id--154 .description--component {
  padding-bottom: 64px;
}
/*********************************************************/
.description--component .col-sm-4 h2 {
  font-size: 45px;
  color: #003366;
  font-weight: 600;
  line-height: 1.1em;
  text-transform: uppercase;
  margin: 0;
}
.description--component .col-sm-4 h3 {
  font-size: 35px;
  font-weight: 300;
  color: #003366;
}
.description--component .col-sm-4 p {
  font-weight: 300;
  font-size: 17px;
}

.paragraph--type--sim img {
  width: 100%;
  height: auto;
}
.description--component .row.text-center .col-sm-3 p.image-title {
  color: #003366;
  font-weight: 600;
  line-height: 1.2;
  margin-bottom: 16px;
  margin-top: 13px;
}
.description--component .content.overlap {
  border-bottom: 6px solid #003366;
  min-height: 565px;
  margin-left: -92px;
  background: #fff;
  margin-top: 39px;
  padding: 64px 40px 64px 96px;
  box-shadow: 0 0 4px #ddd;
}
/* ----------------------Eligiblity field--------------- */
.description--component ul {
  margin: 32px 0px 30px;
}
.description--component ul li {
  margin-bottom: 16px;
}
.description--component ul li::marker {
  color: #ff9900;
}
.description--component ul li a {
  font-weight: 600;
}

/* ------------------------------------------------ HTML WITH BACKGROUND -------------------------------------*/
.html-content-background {
  margin: auto;
  padding: 64px 48px;
}
.html-content-background h4 {
  text-align: center;
  margin-top: 10px;
  font-size: 35px;
  font-weight: 300;
  color: #003366;
  line-height: 1.1em;
  padding-bottom: 24px !important;
  margin-bottom: 0 !important;
}
.html-content-background h1 {
  margin-bottom: 16px !important;
}
.html-content-background text {
  font-weight: 300;
  font-size: 17px;
  line-height: 24px;
  color: #818181;
  margin-bottom: 32px !important;
  display: block;
}

.html-content-background .description--component ol li p {
  font-size: 14px !important;
  margin-bottom: 0px !important;
  font-weight: normal !important;
}
.html-content-background .description--component ol li::marker {
  font-weight: bold;
}

.html-content-background .row .col-sm-6 ul li::marker {
  color: #ff9900;
}

.html-content-background .row.inner-block {
  display: contents;
}

.html-content-background .description--component h3 {
  color: #003366;
  font-size: 23px;
  font-weight: 600;
  line-height: 24px;
  letter-spacing: 0;
}
.html-content-background .description--component {
  padding: 0px;
}

/* --------------------------------Full Html content with background--------------------- */

#full-html-content-background {
  padding: 64px 0px;
  margin-bottom: 64px;
}

#full-html-content-background h4 {
  text-align: center;
  margin-top: 10px;
  font-size: 35px;
  font-weight: 300;
  color: #003366;
  line-height: 1.1em;
  padding-bottom: 24px !important;
  margin-bottom: 0 !important;
}
#full-html-content-background text {
  font-weight: 300;
  font-size: 17px;
  line-height: 24px;
  color: #818181;
  margin-bottom: 20px !important;
  display: block;
}

#full-html-content-background p {
  font-weight: 300;
  font-size: 17px;
  line-height: 24px;
  color: #333333;
}
#full-html-content-background p.text-align-center {
  font-weight: 300;
  font-size: 17px;
  line-height: 24px;
  color: #333333;
  padding: 0 32px;
}
#full-html-content-background a {
  border-bottom: 1.5px solid #b9d9eb;
}

#full-html-content-background ul li::marker {
  color: #ff9900;
}

#full-html-content-background .row.inner-block {
  padding: 0px 60px;
}

#full-html-content-background .description--component h3 {
  color: #003366;
  font-size: 23px;
}
#full-html-content-background .description--component {
  padding: 0px;
}
/* ---------------------- HTML content background advocacy bottom grid ---------------------- */

.html-content-background .advocacy-bottom-grid {
  text-align: center;
}

.html-content-background .advocacy-bottom-grid .col-sm-3 {
  background: #ffffff;
  width: 22.9%;
  padding: 40px 32px;
  margin-right: 30px;
  min-height: 592px;
}

.html-content-background .advocacy-bottom-grid .col-sm-3:nth-child(4) {
  margin-right: 0px;
}

.html-content-background .advocacy-bottom-grid h4 {
  font-size: 35px;
  font-weight: 300;
  color: #003366;
  line-height: 1.1em;
  padding-bottom: 6px;
}

.html-content-background .advocacy-bottom-grid text {
  font-size: 20px;
  line-height: 30px;
  font-weight: 300;
}

.html-content-background .advocacy-bottom-grid .grid-img img {
  width: 96px;
  margin-bottom: 24px;
}

.html-content-background .advocacy-bottom-grid .grid-text h3 {
  text-align: center;
  font-size: 35px;
  font-weight: 300;
  color: #003366;
  padding-bottom: 10px;
  text-transform: none;
  line-height: 1.1em;
}

.html-content-background .advocacy-bottom-grid .grid-text p {
  text-align: center;
  padding-bottom: 10px;
}
.html-content-background .advocacy-bottom-grid a {
  font-weight: 600;
  border-bottom: 1.5px solid #b9d9eb;
  text-transform: uppercase;
}

.html-content-background .advocacy-bottom-grid .grid-text small {
  color: #003366;
  font-size: 17px;
  font-weight: 300;
  line-height: 1.4;
  color: #333333;
  padding-bottom: 10px;
  margin: 0 !important;
}

.html-content-background .advocacy-bottom-grid .footer-text {
  padding-top: 50px;
  font-weight: 300;
  font-size: 17px;
  line-height: 24px;
}

.html-content-background .description--component .four-box {
  margin-bottom: 50px;
}
.field_full_html_paragraph .description--component .content-area {
  padding: 0px 50px;
}

.field_full_html_paragraph
  .description--component
  .content-area
  table.container
  td {
  font-size: 17px;
  color: #333333;
  line-height: 24px;
  font-weight: 300;
  padding: 16px 0 0 0;
  text-align: left;
  vertical-align: top;
}
.field_full_html_paragraph
  .description--component
  .content-area
  table.bottom48 {
  margin-bottom: 48px;
}
/*-------------Counter box section-------------------------*/
.description--component .counter-box h3 {
  font-size: 23px;
  line-height: 29px;
  font-weight: 600;
}
.description--component .counter-box .col-sm-2 {
  text-align: center;
}
.description--component .counter-box .col-sm-2 h1 {
  font-size: 60px;
  font-weight: 200;
  line-height: normal;
}
.description--component .counter-box .col-sm-2 span {
  color: #189cd7;
  font-size: 70px;
}
.description--component .counter-box p.text-center.update-month {
  margin-top: 30px;
}
.description--component .counter-box p em {
  color: #999999;
  font-size: 14px;
  font-weight: 400;
}

.grants-html-section,
.grants-html-section,
.grants-html-section {
  margin: 34px auto;
}



.paragraph.paragraph--type--body .img-wrapper {
  display: flex;
  justify-content: space-around;
  align-items: center;
  height: 245px;
}
.paragraph.paragraph--type--body .img-wrapper .award {
  text-align: center;
}

.paragraph-id--518 #full-html-content-background h2 {
  margin-top: 0px !important;
}
p.primary-hyperoxaluria-full-html-background-img {
  margin-bottom: 16px;
}




.whole-full-html-callout-brochure-area p.margin-bottom-16px {
  margin-bottom: -30px !important;
}


.grants-html-section ul,
.grants-html-section  ul {
  margin: 0px 0px;
}





.bios-card-section > div > .field--item:last-child .bios-card-without-image-field {
  margin-bottom: 0;
}

.grants-html-section  h3,
.grants-html-section h3,
.grants-html-section  h3,
.grants-html-section  h3 {
  margin-top: 0px !important;
}
.grants-html-section  ul,
.grants-html-section  ul,
.grants-html-section  ul,
.grants-html-section  ul {
  margin-bottom: 0px !important;
}

.flip-cards .flip-card {
  position: relative;
  text-align: center;
}
.flip-cards .flip-card div {
  color: white;
  position: absolute;
  height: 100%;
  width: 93%;
  top: 0;
  bottom: 0;
  left: 0;
  right: 0;

  transition: transform 0.4s, background-color 0.2s;
  transform-style: preserve-3d;
}
.flip-cards .flip-card .title {
  font-size: 35px;
  transform: rotateY(0deg);
}
.flip-cards .title strong {
  width: min-content;
  display: block;
  margin: 36% auto;
  font-weight: 600;
  line-height: 1;
}
.flip-cards .flip-card .desc {
  display: flex;
  align-items: center;
  padding: 10%;
  margin: 0 15px;
  background-color: transparent;
  transform: rotateY(90deg);
}
.flip-cards .flip-card .desc strong {
  font-weight: 600;
}
.flip-cards .flip-card:after {
  content: "";
  background-image: url(/sites/default/files/img/buttons-circle-open.svg);
  position: absolute;
  width: 40px;
  height: 40px;
  left: 45%;
  bottom: 24px;
  left: calc(50% - 20px);

  transform: rotate(0deg);
  transition: transform 0.3s;
}
.flip-cards .flip-card.flipped:after {
  transform: rotate(45deg);
}
.flip-cards .flip-card.flipped .title {
  transform: rotateY(90deg);
}
.flip-cards .flip-card.flipped .desc {
  transform: rotateY(0deg);
  background-color: rgb(0 51 102 / 85%);
}

.image-container.d-mobile {
  display: none;
}
@media (min-width: 1001px) {
  #our-science-homepage p.image-title {
    padding: 0;
    margin-bottom: 32px;
  }
  #our-science-homepage .col-sm-3:first-child p.image-title, 
  #our-science-homepage .col-sm-3:nth-child(2) p.image-title {
    max-width: 180px;
    padding: 0 16px;
  }
}

@media (min-width: 768px) and (max-width: 1000px) {
  #our-science-homepage .col-sm-3:nth-child(1) p.image-title ,
  #our-science-homepage .col-sm-3:nth-child(2) p.image-title ,
  #our-science-homepage .col-sm-3:nth-child(3) p.image-title ,
  #our-science-homepage .col-sm-3:nth-child(4) p.image-title {
    max-width: unset !important;
  }
  #our-science-homepage .col-sm-3:nth-child(3) p.image-title br{
    display:none;
  }
}
@media (max-width: 767px) {
  .image-container {
    display: none;
  }
  .image-container.d-mobile {
    display: block;
  }
  
  
}
.our-pipeline {
	background-color: #f4f9fc;
}
.reference-p {
	font-size: 17px !important;
	font-weight: 300 !important;
	font-style: normal;
	line-height: 24px !important;
	letter-spacing: normal;
	color: #333333;
	margin-bottom: 8px;
	padding-bottom: 0px !important;
	text-align: left;
}
.colored-ul, 
.colored-ul li {
	margin-bottom: 0 !important;
}
.paragraph--type--video-popup .center-play-btn .h2-style {
	padding: 0 32px;
}
@media(max-width:767px){
  .row.mobile-reverse {
    display: flex;
    flex-direction: column-reverse;
  }
}
@media only screen and (min-width: 1250px) {
  .page-node-10 .symptoms-area {
    position: relative;
    width: 1100px;
    height: 605px;
    margin: auto;
  }

  .page-node-10 .symptoms-area .rectangle {
    width: 445px;
    height: 445px;
    border: 2px solid #4e5e70;
    border-radius: 20%;
    z-index: 0;
    position: absolute;
    left: 50%;
    top: 80px;
    transform: translateX(-50%);
  }
  .page-node-10 .symptoms-area .rectangle .rect-inner {
    width: 100%;
    height: 100%;
    position: relative;
  }
  .page-node-10 .symptoms-area .whiteout {
    width: 100px;
    height: 20px;
    position: absolute;
    z-index: 10;
    background: #ffffff;
    border: 0px solid red;
  }
  .page-node-10 .symptoms-area .whiteout.top {
    top: -5px;
  }
  .page-node-10 .symptoms-area .whiteout.bottom {
    bottom: -5px;
  }
  .page-node-10 .symptoms-area .whiteout.left {
    left: 70px;
  }
  .page-node-10 .symptoms-area .whiteout.right {
    right: 70px;
  }
  .page-node-10 .symptoms-area p.text {
    position: absolute;
    width: 225px;
    z-index: 10;
  }
  .page-node-10 .symptoms-area p.text.top {
    top: 125px;
  }
  .page-node-10 .symptoms-area p.text.bottom {
    bottom: 125px;
  }
  .page-node-10 .symptoms-area p.text.left {
    left: 75px;
  }
  .page-node-10 .symptoms-area p.text.right {
    right: 75px;
  }
  .page-node-10 .symptoms-area div.img-area {
    display: inline-block;
  }
  .page-node-10 .symptoms-area div.img-area img {
    display: block;
    position: absolute;
    z-index: 2;
  }
  .page-node-10 .symptoms-area img.abdominal {
    top: 0;
    left: 410px;
    width: 80px;
  }
  .page-node-10 .symptoms-area img.numbness {
    top: 0;
    right: 410px;
    width: 70px;
  }
  .page-node-10 .symptoms-area img.confusion {
    bottom: 0;
    left: 410px;
    width: 75px;
  }
  .page-node-10 .symptoms-area img.sun {
    bottom: 0;
    right: 322px;
    width: 161px;
  }
  .page-node-10 .symptoms-area .clearer {
    display: none;
  }  
}

@media only screen and (max-width: 1249px) and (min-width: 800px) {
  .page-node-10 .symptoms-area {
    position: relative;
    width: 100%;
    height: 605px;
    margin: auto;
  }
  .page-node-10 .symptoms-area .rectangle {
    width: 445px;
    height: 445px;
    border: 2px solid #4e5e70;
    border-radius: 20%;
    z-index: 0;
    position: absolute;
    left: 50%;
    top: 80px;
    transform: translateX(-50%);
  }
  .page-node-10 .symptoms-area .rectangle .rect-inner {
    width: 100%;
    height: 100%;
    position: relative;
  }
  .page-node-10 .symptoms-area .whiteout {
    width: 100px;
    height: 20px;
    position: absolute;
    z-index: 10;
    background: #ffffff;
    border: 0px solid red;
  }
  .page-node-10 .symptoms-area .whiteout.top {
    top: -5px;
  }
  .page-node-10 .symptoms-area .whiteout.bottom {
    bottom: -5px;
  }
  .page-node-10 .symptoms-area .whiteout.left {
    left: 70px;
  }
  .page-node-10 .symptoms-area .whiteout.right {
    right: 70px;
  }

  .page-node-10 .symptoms-area p.text {
    position: absolute;
    width: calc(50% - 250px);
    z-index: 100;
  }
  .page-node-10 .symptoms-area p.text.top {
    top: 125px;
  }
  .page-node-10 .symptoms-area p.text.bottom {
    bottom: 125px;
  }
  .page-node-10 .symptoms-area p.text.left {
    left: 0;
  }
  .page-node-10 .symptoms-area p.text.right {
    right: 0;
  }

  .page-node-10 .symptoms-area div.img-area {
    display: inline-block;
  }
  .page-node-10 .symptoms-area div.img-area img {
    display: block;
    position: absolute;
    z-index: 200;
  }
  .page-node-10 .symptoms-area img.abdominal {
    top: 0;
    left: calc(50% - 140px);
    width: 80px;
  }
  .page-node-10 .symptoms-area img.numbness {
    top: 0;
    right: calc(50% - 140px);
    width: 70px;
  }
  .page-node-10 .symptoms-area img.confusion {
    bottom: 0;
    left: calc(50% - 140px);
    width: 75px;
  }
  .page-node-10 .symptoms-area img.sun {
    bottom: 0;
    right: calc(50% - 230px);
    width: 161px;
  }
  .page-node-10 .symptoms-area .clearer {
    display: none;
  }
}

@media only screen and (max-width: 799px) and (min-width: 601px) {
  .page-node-10 .symptoms-area .rectangle {
    display: none;
  }
  .page-node-10 .symptoms-area .symptoms-one,
  .symptoms-area .symptoms-two,
  .symptoms-area .symptoms-three,
  .symptoms-area .symptoms-four {
    float: left;
    position: relative;
    width: calc(50% - 1px);
  }
  .page-node-10 .symptoms-area .clearer {
    clear: both;
  }
  .page-node-10 .symptoms-area .symptoms-one,
  .symptoms-area .symptoms-three {
    text-align: right;
    position: relative;
  }
  .page-node-10 .symptoms-area .symptoms-two,
  .symptoms-area .symptoms-four {
    text-align: left;
    position: relative;
  }
  .page-node-10 .symptoms-area .symptoms-three {
    margin-top: 86px;
  }
  .page-node-10 .symptoms-area div.img-area {
    display: inline-block;
    width: 50%;
    text-align: center;
  }
  .page-node-10 .symptoms-area .symptoms-four div.img-area {
    width: 78%;
  }
  .page-node-10 .symptoms-area p.text {
    position: absolute;
    width: calc(50% - 15px);
    top: 50%;
    transform: translateY(-50%);
  }
  .page-node-10 .symptoms-area .symptoms-four p.text {
    top: 60%;
  }
  .page-node-10 .symptoms-area .symptoms-one p.text,
  .symptoms-area .symptoms-three p.text {
    left: 15px;
  }
  .page-node-10 .symptoms-area .symptoms-two p.text,
  .symptoms-area .symptoms-four p.text {
    right: 15px;
  }
  .page-node-10 .symptoms-area img.abdominal {
    width: 80px;
  }
  .page-node-10 .symptoms-area img.numbness {
    width: 70px;
  }
  .page-node-10 .symptoms-area img.confusion {
    width: 75px;
  }
  .page-node-10 .symptoms-area img.sun {
    width: 161px;
  }
}
@media only screen and (max-width: 600px) {
  .page-node-10 .symptoms-area img.sun {
    width: 161px;
  }
  .page-node-10 .symptoms-area img.sun {
    width: 161px;
  }
  .page-node-10 .symptoms-area .rectangle {
    display: none;
  }
  .page-node-10 .symptoms-area .symptoms-one,
  .symptoms-area .symptoms-two,
  .symptoms-area .symptoms-three,
  .symptoms-area .symptoms-four {
    float: none;
    position: relative;
    width: 100%;
  }
  .page-node-10 .symptoms-area .clearer {
    clear: both;
  }
  .page-node-10 .symptoms-area .symptoms-one,
  .symptoms-area .symptoms-three {
    text-align: right;
    position: relative;
  }
  .page-node-10 .symptoms-area .symptoms-two,
  .symptoms-area .symptoms-four {
    text-align: left;
    position: relative;
  }

  .page-node-10 .symptoms-area div.img-area {
    display: inline-block;
    width: 50%;
    text-align: center;
  }
  .page-node-10 .symptoms-area .symptoms-four div.img-area {
    width: 78%;
  }
  .page-node-10 .symptoms-area p.text {
    position: absolute;
    width: calc(50% - 15px);
    top: 50%;
    transform: translateY(-50%);
  }
  .page-node-10 .symptoms-area .symptoms-four p.text {
    top: 60%;
  }
  .page-node-10 .symptoms-area .symptoms-one p.text,
  .symptoms-area .symptoms-three p.text {
    left: 15px;
  }
  .page-node-10 .symptoms-area .symptoms-two p.text,
  .symptoms-area .symptoms-four p.text {
    right: 15px;
  }
  .page-node-10 .symptoms-area img.abdominal {
    width: 80px;
  }
  .page-node-10 .symptoms-area img.numbness {
    width: 70px;
  }
  .page-node-10 .symptoms-area img.confusion {
    width: 75px;
  }
  .page-node-10 .symptoms-area img.sun {
    width: 161px;
  }
}
.diagram-1 {
   background-color: #f4f9fc;
   padding: 64px 0;
}
@media only screen and (max-width: 1149px) {
  .causes-desktop-area {
    display: none;
  }
}
@media only screen and (min-width: 1150px) {
  .diagram-2 .causes-mobile-area {
    display: none;
  }
}
@media only screen and (min-width: 1001px) {
  .diagram-1 {
    padding: 64px 32px;
  }
  
}
.whiteout {
	background-color: #f4f9fc !important;
}
.page-node-10 .symptoms-area p {
	color: #333;
	font-size: 15px !important;
	line-height: 32px !important;
	letter-spacing: 0;
}
.page-node-10 .sub-title-para.font-20.text-center.mb-48 {
	margin-bottom: 48px !important;
}
@media (min-width: 800px) and (max-width: 850) {
  .page-node-10 .symptoms-area p.text.bottom {
    bottom: 0px;
  }
}
.page-node-10 .causes-main,
.node-15 .causes-main {
  width: 1100px;
  height: 531px;
  position: relative;
  background: url("/sites/default/files/inline-images/porphyria_cause_desktop.png") top no-repeat;
  margin: auto;
  background-size: 1100px auto;
}

/********************cause main and symptoms area code******************/
.page-node-10 .causes-main p {
  position: absolute;
}

.page-node-10 .causes-main p.one {
  left: 152px;
  top: 200px;
}

.page-node-10 .causes-main p.two {
  top: 65px;
  left: 840px;
}

.page-node-10 .causes-main p.three {
  top: 380px;
  right: 0;
  width: 259px;
}

.page-node-10 .causes-mobile {
  max-width: 334px;
  margin: auto !important;
}

.page-node-10 .causes-main p {
  font-size: 17px !important;
  line-height: 24px !important;
}
.colored-ul .li-link.about-link {
	gap: 0;
	padding-left: 16px;
	position: relative;
}
.colored-ul li::before {
	content: "\2022";
	color: #FF9900;
	font-weight: 900;
	display: inline-block;
	width: 1em;
	height: 1em;
	left: 0;
	position: absolute;
}
.colored-ul .li-link.about-link .Link{
  text-transform: unset !important;
	text-decoration: underline #b9d9eb 1.5px !important;
	border-bottom: 0 !important;
	text-underline-offset: 5px;
}


#our-science-homepage .image-title {
	margin-top: 24px;
}
@media(max-width:1000px){
   /*maggi code*/
  #our-science-homepage .image-title{
    margin-top:16px;
  }
  /******    our-pipeline    ******/
  .our-pipeline .row.text-center {
    row-gap: 56px;
  }
  #our-science-homepage .row.text-center .col-sm-3 {
    padding-top: 0;
    padding-bottom: 0;
  }
  .description--component .row.text-center .col-sm-3 p.image-title{
    margin-bottom:0 !important;
  }
  .our-pipeline .dark-button-more {
    margin-top: 32px;
  }  
}